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6180 matches
showing page 1 of 309
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organism
protein
1)
Homo sapiens
TRIM5 - Tripartite motif-containing
protein
5; Capsid-
specific
restriction factor that prevents infection from non-
host
-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-
specific
restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1- UBE2N (als [...]
[a.k.a. NP_149023, CCDS31392.1, DQ301471]
2)
Homo sapiens
IFIT1 - Interferon-induced
protein
with tetratricopeptide repeats 1; Interferon-induced antiviral RNA-binding
protein
that
specifically
binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP- RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'- triphosphate group instead, are
specific
from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the
host
during viral infection. Directly binds PPP-RNA in a non- [...]
[a.k.a. NM_001270929.2, 5UDI, NM_001270929]
3)
Homo sapiens
SLC11A1 - Natural resistance-associated macrophage
protein
1; Divalent transition metal (iron and manganese) transporter involved in iron metabolism and
host
resistance to certain pathogens. Macrophage-
specific
membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis [...]
[a.k.a. R-HSA-425410, SLC11A1-217, R-HSA-1222556]
4)
Homo sapiens
ZNF638 - Zinc finger
protein
638; Transcription factor that binds to cytidine clusters in double-stranded DNA. Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the
host
genome and is transcriptionally repressed. Mediates transcriptional repression of unintegrated viral DNA by
specifically
binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4. Acts as an early re [...]
[a.k.a. ENST00000466975, ENSP00000485618, NP_001014972.1]
5)
Homo sapiens
HACE1 - E3 ubiquitin-
protein
ligase HACE1; E3 ubiquitin-
protein
ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab
proteins
and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division.
Specifically
interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in
host
defen [...]
[a.k.a. ENSP00000428110, Q8IYU2, E9PGP0]
6)
Mus musculus
Ifit1 - Interferon-induced
protein
with tetratricopeptide repeats 1; Interferon-induced antiviral RNA-binding
protein
that
specifically
binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP- RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'- triphosphate group instead, are
specific
from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the
host
during viral infection. Directly binds PPP-RNA in a non- [...]
[a.k.a. mmu:15957, Q64282, AK150609]
7)
Mus musculus
Tyk2 - Non-receptor tyrosine-
protein
kinase TYK2; Involved in intracellular signal transduction by amplifying type I and type II IFN signaling. Phosphorylates the interferon- alpha/beta receptor alpha chain. Plays an essential role in promoting selective immune responses, including innate
host
defense mechanisms and
specific
antiviral activities.
[a.k.a. R-MMU-9020591, ENSMUSP00000001036, O88431]
8)
Mus musculus
Slc11a1 - Natural resistance-associated macrophage
protein
1; Divalent transition metal (iron and manganese) transporter involved in iron metabolism and
host
resistance to certain pathogens. Macrophage-
specific
membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis [...]
[a.k.a. Slc11a1-201, host resistance locus Bcg/Ity/Lsh, R-MMU-425410]
9)
Mus musculus
Ifi44l - Minor histocompatibility antigen HA-28; Precursor of the histocompatibility antigen HA-28 in BALB.B mice. More generally, minor histocompatibility antigens refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by
specific
T-cells. The peptides are derived from polymorphic intracellular
proteins
, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC molecules and its expression on the cell surface can stimulate T- cell responses and thereby trigger graft rejection or graft-versus-
host
dis [...]
[a.k.a. IFL8, uc029upc.1, Interferon-induced protein 44 like]
10)
Mus musculus
Zfp638 - Zinc finger
protein
638; Transcription factor that binds to cytidine clusters in double-stranded DNA (By similarity). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the
host
genome and is transcriptionally repressed. Mediates transcriptional repression of unintegrated viral DNA by
specifically
binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4. Act [...]
[a.k.a. ENSMUST00000203534, ENSMUST00000204713.1, ENSMUST00000032088]
11)
Mus musculus
Hace1 - E3 ubiquitin-
protein
ligase HACE1; E3 ubiquitin-
protein
ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab
proteins
and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division.
Specifically
interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in
host
defen [...]
[a.k.a. R-MMU-1280218, XR_380058, ENSMUST00000059925]
12)
Escherichia coli K12
ihfB - Integration
host
factor (IHF), DNA-binding
protein
, beta subunit; One of the 2 subunits of integration
host
factor (IHF), a
specific
DNA-binding
protein
that functions in genetic recombination as well as in transcriptional and translational control. Has an essential role in conjugative DNA transfer (CDT), the unidirectional transfer of ssDNA plasmid from a donor to a recipient cell. It is the central mechanism by which antibiotic resistance and virulence factors are propagated in bacterial populations. Part of the relaxosome, which facilitates a site- and strand-
specific
cut in the ori [...]
[a.k.a. b0912, AAC73998.1, NP_415432.1]
13)
Escherichia coli K12
ihfA - Integration
host
factor (IHF), DNA-binding
protein
, alpha subunit; One of the 2 subunits of integration
host
factor (IHF), a
specific
DNA-binding
protein
that functions in genetic recombination as well as in transcriptional and translational control. Binds to hundreds of transcriptionally inactive, AT-rich DNA sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome. Has an essential role in conjugative DNA transfer (CDT), the unidirectional transfer of ssDNA plasmid from a donor to a recipient cell. It is the central mechanism [...]
[a.k.a. b1712, AAC74782.1, ECK1710]
14)
Escherichia coli K12
hdeA - Stress response
protein
acid-resistance
protein
; Required for optimal acid stress protection. Exhibits a chaperone-like activity only at pH below 3 by suppressing non-
specifically
the aggregation of denaturated periplasmic
proteins
. Important for survival of enteric bacteria in the acidic environment of the
host
stomach. Also promotes the solubilization at neutral pH of
proteins
that had aggregated in their presence at acidic pHs. May cooperate with other periplasmic chaperones such as DegP and SurA.
[a.k.a. b3510, AAC76535.1, ABE-0011464]
15)
Escherichia coli K12
nanC - N-acetylnuraminic acid outer membrane channel
protein
; Outer membrane channel
protein
allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on
host
cell surfaces) into the bacteria (Probable). NanC
proteins
form high- conductance channels which are open at low membrane potentials and which have a weak anion selectivity; Belongs to the oligogalacturonate-
specific
porin KdgM (TC 1.B.35) family. NanC subfamily.
[a.k.a. b4311, AAC77267.2, P69856]
16)
Achromobacter piechaudii
QWC_22409 - HpcH/HpaI aldolase/citrate lyase family protein 1; COG2301 Citrate lyase beta subunit; Belongs to the HpcH/HpaI aldolase family.
[a.k.a. EJO29317.1, AKG08_04180,
Host specificity protein
]
17)
Achromobacter sp. Root83
KRC77437.1 -
Host
specificity
protein
; Derived by automated computational analysis using gene prediction method:
Protein
Homology; Belongs to the HpcH/HpaI aldolase family.
[a.k.a. ASE30_27920, NZ_LMIU01000011.1,
Host specificity protein
,
host specificity protein
]
18)
Advenella kashmirensis W13003
ETF03534.1 -
Host
specificity
protein
; Derived by automated computational analysis using gene prediction method:
Protein
Homology; Belongs to the HpcH/HpaI aldolase family.
[a.k.a. W822_05920, V8QX19,
Host specificity protein
,
host specificity protein
]
19)
Afipia sp. P5210
ETR76108.1 -
Host
specificity
protein
; Derived by automated computational analysis using gene prediction method:
Protein
Homology; Belongs to the HpcH/HpaI aldolase family.
[a.k.a. X566_16150, W3RIQ8, WP_034469743.1,
Host specificity protein
,
host specificity protein
, ...]
20)
Alcanivorax xenomutans
P40_09630 -
Host
specificity
protein
; Derived by automated computational analysis using gene prediction method:
Protein
Homology.
[a.k.a. ARB45645.1,
Host specificity protein
, 4.1.3.25,
host specificity protein
]
6180 matches
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